Sisters Mainstreet Cafe

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312 Grand Ave
Spencer, IA 51301

Phone: (712) 580-6803

Neighborhood: Spencer

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Popular Menu Items

• Oven Roasted Turkey Club $12.49
• Oven roasted turkey, provolone cheese, avocado, bacon, red onions, tomatoes, lettuce and pesto ranch on a butter croissant.
• Cheese Curds $12.99
• Served with caramel and sweet chili sauce.
• Loaded Fries $12.99
• Smothered in cheddar cheese topped with bacon, green onions and sour cream.
• French Dip $15.99
• Served with fries and a side of au jus.
• Pasta $16.99
• Grilled garlic chicken, sautéed portabella mushroom, garlic, shallots and bacon tossed in a white wine sauce. Substitute shrimp for an additional price. Gluten free pasta for an additional price.

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Reviews for Sisters Mainstreet Cafe

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  3.5 stars - Based on 14 reviews

#19 out of 43 restaurants in Spencer

#1 of 1 Cafe in Spencer

5 star				1 review	7%
4 star				5 reviews	36%
3 star				8 reviews	57%
2 star				0 reviews	0%
1 star				0 reviews	0%

Top Reviews of Sisters Mainstreet Cafe

03/08/2025 - Amber W.
Tucked away in Spencer, this charming cafí© radiates warmth and community spirit, drawing in locals for hearty breakfasts. My wife and I savored the Bargain Breakfast, featuring enormous pancakes that were perfectly fluffy, making it one of the best meals we've enjoyed during our travels.